Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo

Article Abstract:

A simple model describing the cavitation process in the vertebrate embryo is presented, with emphasis on the generation of the hollow tube. In the first stage of the process, the solid embryonic ectoderm is transformed into a columnar epithelium through a signal from the outer layer of endodermal cells and a rescue signal from the contact of the endoderm cells with the basement membrane. The first signal promotes the formation of the cavity through apoptosis, while the second mediates the survival of columnar cells that surround the cavity.

Models, Cavitation, Embryology, Animal embryology

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Cleavage of BlD by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Article Abstract:

Research was conducted to illustrate how BlD, a death agonist member of the Bcl2/Bclx family, can be considered a specific proximal substrate of Casp8 in the Fas signaling pathway. In this study, it was shown that truncated BlD transduces apoptotic signals from cytoplasmic membrane to the mitochondria. The clustering of mitchondria around the nuclei was followed by a loss of mitochondrial membrane potential, nuclear condensation and cell shrinkage.

Mitochondrial membranes, Mitochondrial membrane

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Caspase activation: revisiting the induced proximity model

Article Abstract:

The mechanism of effector caspase activation involves the reorganization of active site loops following the activation cleavage. The possible mechanisms for initiator caspase activation are discussed.

Science & research, Genetic research

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