Skeletal and CNS defects in Presenilin-1-deficient mice
Article Abstract:
The normal physiological role of the Presenilin-1 (PS1) was analyzed in PS1 homozygous mutant mice. Homozygous mutations in the PS1 gene in mice that were derived from four independent embryonic stem cell lines induced death after natural birth or caesarean-section. The PS1 homozygous mutant mice also exhibited gross skeletal and central nervous system abnormalities . Furthermore, brain abnormalities in the mutants was caused by reduced number of progenitor cells and neurons in the ventrolateral region of the ventricular zone.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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T cell receptor delta gene mutant mice: independent generation of alpha-beta T cells and programmed rearrangements of gamma-delta TCR genes
Article Abstract:
Mutant mice deficient in gamma-delta T cell receptor (TCR) were generated to elucidate the molecular mechanisms of the expression of distinct subsets of gamma-delta T cells. The results showed that differential generation of gamma-delta T cell subsets involves an intracellular mechanism acting at the DNA rearrangement level. Furthermore, gamma-delta T cells are not required for the normal development of alpha-beta T cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC-gamma mutant mice
Article Abstract:
Mutant mice deficient in protein kinase C-gamma are unable to coordinate motor activity but learn discrete motion elements such as eyeblinking conditioning. Cerebellar long-term depression is unaffected in the mutants.The motor coordination defects are probably due to the presence of excess multiple climbing fibers in the Purkinje cells of the mutants.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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