Sox2 is required for development of taste bud sensory cells

Article Abstract:

Sox2 finds expression in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae and mature taste cells and low levels in filiform papillae. The loss-of-function and gain-of-function studies have suggested that Sox2 functions in a dose-dependent manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud sensory cells versus keratinocytes.

North Carolina, Analysis, Epithelial cells, Genetic transcription, Transcription (Genetics), Embryonic stem cells

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Rapid accumulation of mutations during seed-to-seed propagation of mismatch-repair-defective Arabidopsis

Article Abstract:

The effects of sustained mutational loading during multigenerational propagations, appearance of apparent single- and perhaps multiple-locus phenotypes and an overall trend toward decreased fitness are demonstrated. Analyses of insertion /deletion mutation at six repeat-sequence loci showed each Atmsh2-1 line to have evolved its own fingerprint the results of as many as 10 microsatellite mutations in a single line.

Arabidopsis thaliana, Genetic research

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SOX2 is a dose-dependent regulator of retinal neural progenitor competence

Article Abstract:

The requirement for SOX2 during eye development was directly assessed by generating a gene-dosage allelic series of Sox2 mutations in the mouse. The Sox2 mutant mice display a range of eye phenotypes consistent with human syndromes and the severity of these phenotypes directly relates to the levels of SOX2 expression found in progenitor cells of the neural retina.

United States, Physiological aspects, Eye, Cellular control mechanisms, Cell regulation

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