Sprouty, an intracellular inhibitor of Ras signaling
Article Abstract:
Many aspects of cell fate are controlled by intracellular signaling via the epidermal growth factor receptor (Egfr). This is amply illustrated in Drosophila where Egfr guides cell proliferation, survival and differentiation in many tissues. The function of Sprouty, an inhibitor of Egfr signaling in Drosophila, is examined to shed light on Egfr inhibition. Sprouty is shown to interact genetically with the receptor tyrosine kinases Torso and Sevenless. It is also proven that Sprouty is an intracellular protein associated with the inner surface of the plasma membrane.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila
Article Abstract:
Regulation of epidermal growth factor activation is mediated by the membrane proteins Star and Rhomboid-1 by ligand activation at the cell surface. Data indicate that they regulate intracelular trafficking and proteolysis of the ligand Spitz, which mediates epidermal growth factor activation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
Article Abstract:
Research indicates that the membrane protein Rhomboid-1 is an intra-membrane serine protease and cleaves the growth factor Spitz, leading to the activation of Drosophila epidermal growth factor receptor.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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