Starvation stress modulates the expression of the Aspergillus nidulans brlA regulatory gene
Article Abstract:
A study of the regulation of the brl regulatory gene expression in Aspergillus by starvation stress using a media-shifting scheme that activates latent sporulation and brlA-lacZ as an activation marker reveals that brlA transcription is activated to varying extents by nitrogen and carbon starvation stress. An inverse relationship exists between the quantity and rate of brlA mRNA, and the conidiophore morphological complexity. Sporulation occurs only when mycelia are transferred to starvation conditions in buffered standard minimum medium, indicating that a high variation from external neutral pH inhibits total activation of brlA.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1995
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Identification of new regulatory genes controlling synthesis of folate-dependent enzymes in Aspergillus nidulans
Article Abstract:
A research on metH2 mutants was conducted to identify other several enzymes involved in folate metabolism of aspergillus nidulans. Six methionine-independent strains were isolated through media, culture and enzyme assays. Results of the study showed that in three of the isolates reversion, intragenic suppressor mutation in the metH2 locus occurred. The other genes designated as folA, folB and folC, also have undergone strains suppressor mutation. Furthermore, the synthesis of folate-dependent enzymes in A. nidulans are controlled by a system wherein homocycteine function as an inducer and methionine as a co-repressor.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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The TBP gene from Aspergillus nidulans - structure and expression in Saccharomyces cerevisiae
Article Abstract:
Aspergillus nidulans transcription initiation complexes from the isolation and characterization of the TATA-binding protein (TBP) gene were analyzed. Saccharomyces cerevisiae cells which contained the A. nidulans TBP gene grew poorly at 30 and 35 degrees celsius on glycerol and galactose mediums, respectively, contrary to the fact that they could grow in the presence of copper ions or aminotriazole at this temperature. The function of A. nidulans TBP gene was suggested to be different in some yeast transcription activation pathways.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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