Structural analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
Article Abstract:
A combination of electron microscopy and x-ray crystallography are used to describe the structures of full-length HtpG, the Escherichia coli hsp90 ortholog, revealing dramatic nucleotide-dependent structural rearrangements, from an open conformation in the nucleotide-free state that is accessible to client proteins, to a compact ADP-bound state. The results reveal a general mechanism by which nucleotide binding and hydrolysis control the binding and release hsp90 client proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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A structural superfamily of growth factors containing a cystine knot motif
Article Abstract:
Structural analyses of nerve growth factor, transforming growth factor beta and platelet-derived growth factor revealed how the prototypical members of three supposedly unrelated families adopt similar protomeric folds that contain the cystine knot motif. These growth factors form a new structural superfamily since the cystine knot was found to be unique to them. The evolutionary implications of the structure of these molecules are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN
Article Abstract:
Cryo-electron microscopy at 25 A resolution was used for the determination of the structure of dengue virus (DENV) in complex with the carbohydrate recognition domain (CRD) of dendritic cell-specific ICAM3 grabbing noninteger (DC-SIGN). One CRD monomer bounded two glycosylation sites at Asn67 of two neighboring glycoproteins in each isothermal asymmetric unit while the third Asn67 residue remained vacant.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
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