Structural and functional differences in two cyclic bacteriocins with the same sequences produced by lactobacilli
Article Abstract:
L. reuteri LA6 and lactobac illus gasseri LA39 isolated from feces of the sane human infant are found to produce similar cyclic bacteriocins that cannot b distinguished by molecular weights or primary amino acid sequences. The findings suggest that the different D-lanine contents of the bacteriocins may cause the differences in modes of action, amounts of potassium ion efflux and secondary structures.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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Production of novel rapamycin analogs by precursor-directed biosynthesis
Article Abstract:
An investigation on the use of precursor-directed biosynthesis to create new rapamycin analogs by substitution of unusual L-pipecolate analogs in place of the normal amino acid is presented. The results suggest that the L-pipecolate analog (plusmn)-nipecotic acid inhibits the biosynthesis of L-pipecolate, thereby limiting the availability of this molecule for rapamycin biosynthesis.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2005
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L-alanine auxotrophy of Lactobacillus johnsonii as demonstrated by physiological, genomic, and gene complementation approaches
Article Abstract:
A study using a chemically defined medium without L-alanine, Lactobacillus johnsonii is demonstrated to be strictly auxotrophic for that amino acid, is presented. A comparative genetic analysis showing that all known genes involved in L-alanine biosynthesis are absent from the genome of L. johnsonii, is also presented.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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