Subcellular mobility of the calpain/calpastatin network: An organelle transient

Article Abstract:

The organization of the calpain/calpastatin (Cp/Cs) network is dependent on its association with organelles and it has provided a mechanism for orderly regulation and proximity to substrates, and facilitated translocation of this protease to appropriate sites in the cell. The results have shown that Cp and its regulatory moieties associate with organelles to facilitate the activation of this protease resulting in the cleavage of substrates and aid in its translocation throughout the cell.

Alzheimer's disease, Structure, Hydrophobic effect, Calpain

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Lentiviral nuclear import: A complex interplay between virus and host

Article Abstract:

The study provides an insight into the phenomenon of the lentiviral nuclear import, as the signal-facilitating translocation of the viral preintegration complex (PIC) is found to take place through the nuclear pore complex (NPC). The results give a complete overview of the nuclear import phenomenon, also explaining the interplay existing between the virus and host and the various factors that lead to nuclear import.

Analysis, HIV infection, HIV infections, Polymerase chain reaction

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Evolution at the host-retrovirus interface

Article Abstract:

The characterization of endogenous retroviruses has enabled a construction of a detailed picture of retroviral diversity across vertebrate species. The identification of ongoing genome invasion in wild populations and the characterization of conserved mechanisms of innate antiretroviral defense have provided insights into the biology and evolution at the host-retroviruses interfaces.

United States, Host-virus relationships

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