The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor
Article Abstract:
Results demonstrate that the bone morphogenetic protein-4 activity and signaling capability is influenced by its cleavage sites mediated by furin. Data show that cleavage at a consensus furin site enables subsequent cleavage at a nonconsensus site. The protein cleaved at two sites are more active and signal over a greater range.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation
Article Abstract:
Results demonstrate that synergistic regulation of vertebrate muscle development involves Drosophila gene dachshund2, vertebrate homologs Eya2 and Six1 and physical interaction between the respective gene encoded proteins. This study illustrates a new regulatory pathway for myogenic specification in the embryonic precursors of the skeletal muscle development.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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- Abstracts: Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification
- Abstracts: Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins
- Abstracts: E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genome-wide mapping of Polycomb target genes unravel their roles in cell fate transitions