E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

Article Abstract:

Results show that the E2F transcription factors act as transcriptional repressors in association with the retionoblastoma protein family members that are involved in the development and cell proliferation. Data reveal that E2Fs can independently control the expression of genes involved in cell proliferation besides regulating apoptosis, differentiation, and development.

Italy, Statistical Data Included, Analysis, Genetic regulation, Gene expression, Genetic transcription, Transcription (Genetics), Cell proliferation, Retinoblastoma

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Genome-wide mapping of Polycomb target genes unravel their roles in cell fate transitions

Article Abstract:

The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Their target genes are identified using genome-wide location analysis in human embryonic fibroblasts, and regulation of PcG target genes show that PcGs are part of a preprogrammed memory system established during embryogenesis, marking key genes for repressive signals during subsequent developmental and differentiation processes.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Cancer & Cell R&D, Cancer research, Cancer, Cell division, Embryology, Fibroblasts, Oncology, Experimental

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The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Article Abstract:

A study to show that the ability of the oncogene BMI1 to repress the INK4A-ARF locus requires its direct association and is dependent on the continued presence of the EZH2-containing polycomb-Repressive Complex 2 (PRC2) complex was conducted. The down-regulation of EZH2 leads to loss of H3K27me3, displacement of BMI1, and activation of INK4A transcription, resulting in senescence and provides a model for the activation of INK4A-ARF locus and polycombs contribution to cancer.

Cells, Oncogenes, Cell aging

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