The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats
Article Abstract:
The Arabidopsis NPR1 gene was cloned using a map-based method and was observed to encode a unique protein containing ankyrin repeats. The gene was found to control the onset of systemic resistance and affect local acquired resistance, the ability of plants to inhibit the spread of virulent pathogen infections. Mutations that were observed to terminate NPR1 function included conversion of a cysteine to a tyrosine, disruption of the ankyrin repeat consensus sequence and truncations of the protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs
Article Abstract:
A study of the crystal structures of two Sm protein complexes, D3B and D1D2, revealed that the seven Sm proteins B/B', D1, D2, D3, E, F and G have a common fold with a N-terminal helix followed by a strong bent five-stranded antiparallel beta sheet. The D3B and D1D2 dimers were also found to be superposed closely in their core regions. Results also suggested that the seven Sm proteins can form a closed ring and the spliceosomal small nuclear RNAs are bound in the cationic central hole.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1
Article Abstract:
A screening for suppressors of npr1-1 was conducted to identify additional regulators of systemic acquired resistance (SAR). Results revealed the sni1 mutant that displays near wild-type levels of PR1 expression and resistance to pathogens after induction. The recessive sni1 mutation was found to restore SAR in npr1-1, suggesting that wild-type SNI1 may function as a negative regulator of SAR. The cloning of the SNI1 gene showed that it encodes a leucine-rich nuclear protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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