The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
Article Abstract:
Programmed cell death in the nematode Caenorhabditis elegans requires the engulfment of dying or dead cells by other cells. This engulfment of cellular corpses is mediated by the gene product of ced-7. The protein CED-7 is localized in the plasma membrane and bears some degree of sequence homology with the mammalian ABC transporter family. It is postulated that CED-7 translocates the molecules that serve as communication signals between dying and engulfing cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
Article Abstract:
The egl-1 gene of Caenorhabditis elegans encodes a polypeptide that interacts with the gene product of ced-9, a gene that protects against apoptosis. Gain-of-function mutation of egl-1 induces apoptosis in hermaphrodite-specific-neurons through programmed cell death. It is postulated that the gene product of egl-1 directly interacts with CED-9 to inhibit its activity with the subsequent release of a cell death activator complexed with it.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans
Article Abstract:
Results suggest that the ABC transporter protein CED-7 promotes engulfment of cell corpse by ced-1 gene encoded CED-1 protein in C. elegans. Data indicate that CED-1 exposes a phospholipid ligand on the surfaces of cells undergoing programmed apoptosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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