The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization
Article Abstract:
A study was done to describe the phenotypic and molecular characterization of the mutant spe-9 gene in the nematode worm C. elegans. This gene encodes a sperm transmembrane protein with an extracellular domain that contains EGF-like repeats which involved in extracellular functions such as adhesive and ligand-receptor interactions. The overall structure of the predicted mutant phenotype SPE-9 protein is similar to that of ligands for the Notch/LIN-12/GLP-1 transmembrane receptors. Results suggest that SPE-9 functions in specialized cell-cell interactions required for fertilization.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans
Article Abstract:
Research was conducted to characterize genes associated with epidermal morphogenesis in Caenorhabditis elegans. Vab-1 mutants were isolated based on their morphogenetic defects in head epidermis while sequences of genomic DNAs from the mutants were amplified. Results showed that the null phenotype of vab-1 has a variable defect in epidermal morphogenesis. They also indicated that signaling through receptors and ligands was correlated in axon guidance and topographic mapping.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
A gene-centered C. elegans protein-DNA interaction network
Article Abstract:
A study employed 'gene-centered' high-throughput yeast one-hybrid (Y1H) assays to identify 283 interactions between 72 Caenorhabditis elegans digestive tract gene promoters and 117 proteins. The resulting protein-deoxyribonucleic acid interaction (PDI) network is highly connected and enriched for transcription factors (TFs) that are expressed in the digestive tract.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in Dictyostelium
- Abstracts: PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
- Abstracts: The dual-role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation. Magnetoreception
- Abstracts: Bird evolution in the Eocene: Climate change in Europe and a Danish fossil fauna. Thermal behavior of crustaceans
- Abstracts: Regulation of the alginate biosynthesis gene algC in Pseudomonas aeruginosa during biofilm development in continuous culture