The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development
Article Abstract:
A Drosophila Activin receptor, Baboon, signals using dSmad2 and controls cell proliferation but larval development patterning. The role of Baboon (Babo), a type I Activin receptor called Atr-I in the past, in Drosophila development has been described. Aspects of the Babo intracellular signal-transduction pathway have been characterized. A new Drosophila Smad has been identified. It is called dSmad2 and is closely related to vertebrate Smads 2 and 3. A novel Drosophila Activin/TGF-beta pathway has been defined and is analogous to the vertebrate counterpart.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity in the early mouse embryo
Article Abstract:
Research was conducted to study Smad2 mutant embryos developed using ES cell technology. Embryos were dissected free of maternal tissues while heterozygous Smad2 mice were crossed to animals with the nodal.LacZ allele. Results showed that the loss of Smad2 activity disturbed the development of the primitive endoderm lineage. They also showed the presence of Bmp4 transcripts in the marginal zone between the animal and vegetal hemispheres.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
- Abstracts: Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in dictyostelium
- Abstracts: Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Magnitude of binocular vision controlled by Islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding
- Abstracts: Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Motor neuron-derived retinoid signaling specifies the subtype identity if spinal motor neurons
- Abstracts: Photosynthate partitioning and fermentation in hot spring microbial mat communities. Cultivation of aerobic chemoorganotrophic proteobacteria and gram-positive bacteria from a hot spring microbial mat