The Drosophila mei-S332 gene promotes sister-chromatid cohesion in meiosis following kinetochore differentiation
Article Abstract:
Analysis of alleles of the Drosophila mei-S332 gene revealed that the native gene promotes sister-chromatid cohesion in meiosis I. The mutant alleles resulted in precocious separation of sister-chromatid pairs in both phases of meiosis. The mutations adversely affected segregation of the major autosomes in both sexes, particularly for chromosome 3. Sex-specific differences in function were also observed for some alleles. The product of this gene is not required for homolog pairing nor is an absolute requirement during mitosis.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions
Article Abstract:
A Drosophila sister chromatid cohesion gene, mei-S332, promotes association of sister chromatids and plays an important role in sister chromatid cohesion during meiosis. It is localized in the centromere region of meiotic chromosomes until anaphase II. Cytological studies show that mei-S332 disappears from the chromosome at this time by dissolving during anaphase II. These results suggest that the absence of mei-S332 is also essential for sister chromatid separation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Sister-chromatid misbehavior in Drosophila ord mutants
Article Abstract:
A study was conducted to analyze ord gene mutants in both sexes of Drosophila. In such cases, sister chromatids prematurely disjoin in meiosis. Five new alleles of ord are isolated and examined as homozygotes and as locus deficiencies. Results show that ord functions occur early in both meiotic processes. All alleles exhibited full viability even under trans deficiency conditions.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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