Development: the natural history of genes
Article Abstract:
The natural history of genes and developmental biology are discussed in this review article organized using the control of yeast mating-type as a skeleton for recounting the discoveries of recent decades. Developmental biology and its study make the renewal of life more astounding. Wild genes seen from the genome projects are fun to consider. The life of Carolus Linnaeus, botanist and professor of medicine is discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oognenesis
Article Abstract:
D-cbl, a negative regulator of the Egfr pathway, has been shown to be necessary for Drosophila oognenesis dorsoventral patterning. Two levels of control are required to establish different follicle cell fates through the precise regulation of Egfr activity, which must be repressed by the activity of D-cbl to guarantee absence of signaling in the ventral-most follicle cells. Efgr is the epidermal growth factor (EGF) receptor and is activated by the asymmetrically localized Gurken to determine dorsal follicle cell fates.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation
Article Abstract:
A novel gene jelly belly mediates visceral mesoderm development in Drosophila and the gene encoded protein contains an LDL receptor repeat. In mutants lacking this gene, the visceral mesoderm precursors fail to migrate or differentiate without visceral muscle development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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