The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
Article Abstract:
Analysis of the influence of mutant and wild-type SH-PTP2 RNA, the vertebrate homologs of Drosophila corkscrew, on the embryogenesis of Xenopus shows that SH-PTP2 is essential for early vertebrate formation. An internal phosphatase domain deletion induces posterior truncations and inhibits the activation of fibroblast growth factor (FGF)-induced mitogen-activated protein (MAP) kinase and induction of mesoderm by activin and FGF. SH-PTP2 thus functions as a positive component of the FGF signaling pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning
Article Abstract:
The dorsoventral, proximodistal, and anteroposterior axes are linked by the respective signals WNT7a, fibroblast growth factor 4 (FGF4), and Sonic hedgehog (SHH) during vertebrate limb development and patterning. The dorsal ectoderm and FGF4 are required to maintain Shh expression. The wnt7a gene, expressed in dorsal ectoderm, gives the signal required for Shh expression and formation of posterior structures.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A
Article Abstract:
The topology of the catalytic domain of Cdc25A, a cell cycle control phosphatase has been determined at a resolution of 2.3 angstrom units. The domain consists of an alpha/beta motif different from that of other phasphatases. However, it shares some similarity with a sulphur-transfer protein, rhodanese. The structural and functional roles of specific amino acid residues in this enzyme are presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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