The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

Article Abstract:

The adaptor protein Shc links a subset of beta(sub 1) and alpha(sub v) integrins to the MAP kinase pathway. The association of these integrins with Shc is shown to regulate cell survival and cell cycle progression, in response to the extracellular matrix. Results of mutagenesis and dominant-negative inhibition studies show that Shc is necessary and sufficient for the activation of the MAP kinase pathway. On the other hand, adhesion mediated by integrins not linked to Shc leads to cell cycle arrest and apoptosis, even in the presence of mitogens.

Cell cycle, Cell adhesion

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A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

Article Abstract:

A study showed that the caveolin-1 and Fyn play an important role in integrin signaling and anchorage-dependent cell growth. The caveolin-1 serves as a membrane adaptor to connect the integrin alpha subunit to the tyrosine kinase Fyn. The Fyn is activated and binds to Shc through its SH3 domain upon integrin ligation. The Shc is then phosphorylated at tyrosine 317 and recruits Grb2.

Growth factors, Protein tyrosine kinase, Protein-tyrosine kinase, Tyrosine

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