The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord

Article Abstract:

The basic helix-loop (bHLH) gene Olig3 is expressed in progenitor cells that generate class A (dI3) neurons and it is shown that Olig3 is an important factor in the development of these neuronal cell types. It is concluded that Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons.

United States, Gene expression, Neurons, Spinal cord

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CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells

Article Abstract:

The migrating muscle progenitors express the chemokine receptor CXCR4. Gab1 encodes an adaptor protein that transduces signals elicited by tyrosine kinase receptors and plays a role in the migration of muscle progenitors cells, indicating that CXCR4 and Gab1 interact genetically.

Genetic aspects, Muscles, Tyrosine, Chemokine receptors, Skeletal muscle

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The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic Beta cells and intestinal endocrine cells

Article Abstract:

The Insm1 (insulinoma-associated 1, IA-1) gene encodes a Zinc-finger factor that was discovered in an insulinoma cDNA library. A demonstration that pancreatic and intestinal endocrine cells express Insm1 and require Insm1 for their development is presented.

Pancreatic beta cells, Zinc finger proteins

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