The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

Article Abstract:

Basic helix-loop-helix (bHLH) protein PTF1-p48 appears to be needed for differentiation and/or proliferation of the cell lineage for the exocrine pancreas. A mouse with a null mutation of the p48 allele does not have any exocrine pancreatic tissue or associated products. The exocrine pancreas seems to be necessary for the endocrine pancreas to be assembled correctly. When the exocrine pancreas is absent, cells migrate to the spleen instead.

Genetic aspects, Cell differentiation, Cell proliferation, Pancreas, Exocrine glands

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MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

Article Abstract:

The polypyrimidine tract-binding protein (PTB) and its neuronal homolog nPTB regulators control the splicing patterns during neuron and muscle differentiation by repressing certain exons in early myoblasts. It is shown that such repression results from its targeting by the muscle-restricted microRNA miR-133.

Science & research, Gene expression, Protein binding, Genetic research

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