The biology of hypoxia: The role of oxygen sensing in development, normal function, and disease

Article Abstract:

The report on the first Keystone Meeting on the Biology of Hypoxia summarizes the understanding of key genes and pathways involved in oxygen sensing required for normal development, which are dysregulated in disease states. The identification of oxygen-regulated proteins, such as the hypoxia-inducible factor (HIF) family transcription factors, serves as a paradigm for oxygen sensing at the molecular level, but probably represents only one example on a much larger theme of protein regulation in response to hypoxia.

Oxygen, Industrial Gas Manufacturing, Industrial gases, Hypoxia, Anoxia, Proteins, Chemical properties

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The transcription factor HIF-1[alpha] plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Article Abstract:

A study to demonstrate importance of transcription factor, HIF-1[alpha] in various hematopoietic cells, in the growth factor-dependent regulation of aerobic as well as anaerobic glycolysis is described. Results show that HIF-1[alpha] factor helps in decrement of the glucose-dependent anabolic synthesis and increases lactate production leading to regulation of glucose metabolism even absence of hypoxia.

Hematopoietic stem cells, DNA binding proteins, Glucose metabolism

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