Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway
Article Abstract:
The tumor necrosis factor-[alpha] (TNF[alpha])-mediated inhibition of myogenic differentiation is found to be dependent on p53 through a PW1-mediated pathway. The p53 plays a novel role in mediating muscle stem cell behavior and muscle atrophy, and has pointed towards new targets for the therapeutic treatment of muscle wasting (cachexia).
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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'Drosophila' PIWI associates with chromatin and interacts directly with HP1a
Article Abstract:
The PIWI protein interacts with heterochromatin protein 1a (HP1a) in 'Drosophila' and is a chromatin-associated protein. A direct interaction between PIWI and HP1a determines the epigenetic state of the genome.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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