Y do we drink?

Article Abstract:

The neuropeptide Y (NPY) is being implicated in the regulation of mammalian reactions to alcohol. The study conducted by Thiel et al published in 'Nature,' demonstrated that genetic manipulation altering the NPY levels in mice influenced the sensitivity of these animals to the sedative effects of ethanol and their observed preferences for the substance. NPY mediated multiple behavioral and physiological processes observed in the experimental mice. It modulated feeding and emotional responses and produced potent analgesis effects.

Mammals, Neuropeptide Y

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Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway

Article Abstract:

Drosophila melanogaster was used in the investigation of the physiology of alcoholism. A number of studies have postulated the involvement of cyclic AMP (cAMP) in the molecular mechanism of the addiction process. Drosophila studies using an inebriometer and experimental manipulation of cAMP levels reveal that this cyclic nucleotide plays a role in the establishment of alcoholism. Further, there appears to be a genetic predisposition to alcohol tolerance in the fruit fly.

Research, Alcoholism, Drosophila, Cyclic adenylic acid, Cyclic adenosine monophosphate

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Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics

Article Abstract:

The evidence for mechanisms linking actin dynamics to behavioral responses to ethanol is provided from study report about Eps8, which regulates acute ethanol sensitivity and ethanol consumption in mice. From the result it is concluded that Eps8 is required in the N-methyl-D-aspartate receptor-signaling pathway leading to activation of cofilin and actin-filament turnover.

All Other Basic Inorganic Chemical Manufacturing, Industrial organic chemicals, not elsewhere classified, Industrial inorganic chemicals, not elsewhere classified, Ethanol, Ethyl Alcohol Manufacturing, Nitrogen Compounds, Analysis, Actin, Alcohol, Denatured

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