The carboxyl terminus of phage HK022 Nun includes a novel zinc-binding motif and a tryptophan required for transcription termination
Article Abstract:
The carboxyl terminus of phage HK022 Nun has been found to have a novel zinc-binding motif and a tryptophan required for transcription termination. The role of certain amino acid residues in the carboxy-terminal domain in transcription termination have been studied by NMR spectroscopy, by in vitro and in vivo functional assays, and by mutagenesis. Inhibition of BOXB binding was studied.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Bromodomain factor 1 corresponds to a missing piece of yeast TFIID
Article Abstract:
Two proteins, Bromodomain factor 1 (Bdf1) and its homolog (Bdf2), have been isolated in studying the functions of TAFs and TFIID, a basal transcription factor, using a yeast two-hybrid screen. TFIID comprises TATA-binding protein (TBP) and 10-12 TBP-associated factors (TAFs). Bdf1 seems to correspond to the carboxy-terminal region of higher eukaryotic TAF(sub.II) 250. It appears the interaction between TFIID and Bdf1 is important for gene expression that is proper.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation
Article Abstract:
Study of the genome of the radiation-resistant eubacterium Deinococcus radiodurans is discussed in this research communication. The genome comprises an ortholog of an RNA-binding protein, Ro60-kD autoantigen, previously identified only in higher eukaryotes. It was found that Ro ribonucleoproteins are a factor in UV resistance in D. radiodurans.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
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