The centromere frontier: kinetochore components, microtubule-based motility, and the CEN-value paradox
Article Abstract:
A review of studies on the components and functions of kinetochores is presented. The kinetochore is an integrated nucleic acid and protein complex which directs chromosome movements during meiosis and mitosis. The assembly of kinetochore components at the centeromere DNA and their attachment to the spindle fibers produced by the microtubule organizing centers are responsible for the fidelity of chromosome segregation during meiosis and mitosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Mother and daughter are doing fine: asymmetric cell division in yeast
Article Abstract:
Yeast cells exhibit the ability to change their mating types as soon as they have produced at least one daughter cell. This phenomenon, known as mating-type switching, leads to the production of haploid cells of two different mating types which can then form a diploid zygote. The genes regulating the transition in mating type in a mother cell have been identified and localized on the yeast genome.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Vertebrate shugoshin links sister centromere choesion and kinetochore microtubule stability in mitosis
Article Abstract:
Premature sister centromere separation in mitosis is prevented by the localization of the related vertebrate Sgo to kinetochores. The demonstration of this essential fact provides an explanation for the differential cohesion seen between the arms and the centromeres of mitotic sister chromatids.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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