The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling

Article Abstract:

Talpid3 is a chicken mutant with abnormal limb patterning and malformations in other regions of the embryo known to dependent on Hedgehog signaling. Talpid3 phenotype is completely ligand independent in several regions of the embryo and this talpid3 is required for the function of Gli repressor and activator in the intracellular pathway as Gli3 processing is abnormal in talpid3 mutant cells but Gli3 can still translocate to the nucleus.

Chickens, Animal embryo

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A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

Article Abstract:

A study was conducted for demonstrating that a gradient of Gli activity was sufficient for mediating the full-range of Sonic Hedgehog (Shh) responses in the neural tube. The data suggest that the Shh signaling is transduced into a gradient of Gli activity, which is responsible for orchestrating the patterning of the ventral neural tube.

Analysis, Neuroglia, Glia, Neural tube, Gene silencing

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Establishing neuronal circuitry: Hox genes make the connection

Article Abstract:

The relationship between hindbrain segments and neural crest cells that migrate to populate the branchial arches is analyzed. The results revealed that the registration of positional identity underlying motor neuron circuitry involves coordinated expression of multiple Hox genes in distinct populations of neural crest cells.

Vertebrates, Neural crest, Embryo

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