The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila
Article Abstract:
An attempt is made to show that the mutation in the DHR4 orphan nuclear receptor result in larvae that precociously leave the food to form premature prepupae, resulting in abbreviated larval development that translates directly into smaller and lighter animals. The DHR4 coordinates growth and maturations in Drosophila by mediating endocrine responses to the attainment of critical weight during larval development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila
Article Abstract:
A study was conducted to show that DHR78 is an obligate partner for Moses (Middleman of seventy-eight signaling), a sterile [alpha] motif domain-containing cofactor that requires DHR78 for its stability. Genetic interactions between DHR78 and Moses resulting in a similar phenotype suggest that the relative dose of Moses and DHR78 regulates growth and prevents cancer.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway
Article Abstract:
Research describes an ecdysteroid signaling pathway in Drosophila mediated by DHR38 nuclear receptor. Data indicate that the pathway requires heterodimerization with ultraspiracle and does not involve binding of either ecdysteroids or cofactors of DHR38. X-ray crystal structure of DHR38 is presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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