The glucocorticoid receptor is required for stress erythropoiesis

Article Abstract:

The glucocorticoid receptor (GR) has been shown to be necessary for stress erythropoiesis, which requires GR-mediated regulation of erythroid progenitor (ebl) proliferation. The impact of the GR on erythropoiesis in vivo has been studied using GR-deficient mice or those expressing a GR defective for transactivation. Mice lacking the GR die at birth so fetal livers were used after onset of definitive erythropoiesis at E14.5. In vitro sustained primary ebls proliferation must have intact GR.

Austria, Germany, Statistical Data Included, Physiological aspects, Adrenocortical hormones, Hormone receptors, Stress (Physiology), Cytochemistry, Erythropoiesis

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Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth

Article Abstract:

Mice carrying a hepatocyte-specific inactivation of the glucocorticoid receptor (GR) gene show a dramatic reduction in body size. Study reveals that the model in which GR acts as a coactivation for stat5-dependant transcription upon GH stimulation and reveal an essential role of hepatic GR in the control of body growth.

Health aspects, Genetic research

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Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression

Article Abstract:

The normal postnatal growth is dependent on the activity of glucocorticoid receptor function in hepatocytes. The glucocorticoid receptor stat 5 undergoes tetramerization to mediate the transcription of genes involved in the growth regulation.

Gene expression

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