The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development
Article Abstract:
Yeast cells expressing Xenopus genes produce the FRL1 and FRL2 proteins that bind and stimulate the fibroblast growth factor receptor (FGF). FRL1 is related to the epidermal growth factor family while FRL2 distantly belongs to the angiogenin/ribonucleases. The overexpression of these proteins in Xenopus embryos causes gastrulation and head morphology defects. This is due to the stimulation of mesoderm and neural-specific genes which is suppressible by suppressing the FGF receptor. FRL1 is mainly expressed during gastrulation and neurulation while FRL2 is expressed in axial mesoderm and the brain.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
Article Abstract:
The operation of cellular signal transduction networks is made possible by the action of direct and indirect pathways. One mechanism that connects these signal transduction pathways to actin polymerization stimulation is described. The mechanism involves the regulation of the Arp 2/3 complex, which is needed for actin nucleation, by N-WASP. It is also shown that this interaction can be enhanced by the presence of phosphatidylinositil (4,5 ) biphosphate and Cdc42.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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John Newport 1951-2005
Article Abstract:
John Newport was a distinguished professor of biology at the University of California, San Francisco. He died on December 26th, 2005 after a brief illness of pancreatic cancer.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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