The sins of the fathers and mothers: genomic imprinting in mammalian development
Article Abstract:
The discovery of genomic imprinting in mammalian development in the 1980s has presented scientific communities with the paradox that parents influence gene expression in their offspring by inactivating the paternal X chromosome in all somatic cells. The growth effects displayed by mutations were linked to behavioral effects by a theory for the evolution of imprinting espoused by Haig and Westoby. The model proposed that paternally expressed genes should promote growth while maternally expressed genes should slow it down at any period when the mother is the sole source of nutrition.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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The genetic basis for specific anosmia to isovaleric acid in the mouse
Article Abstract:
A study of two inbred mouse strains shows that the differences in the ability to recognize odorant isovaleric acid occurs due to the loss of a receptor protein/proteins. High resolution genetic mapping is useful in the detection of genes responsible for the recognition of specific odorants. The capacity to detect the odorant involves many loci. One of these loci is located on the terminal region of chromosome 4 while another lies on the distal tip of chromosome 6. The detection of odorants in mammals involves a group of 100 to 1000 seven transmembrane domain receptor proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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