The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
Article Abstract:
Transformation/transcription domain-associated protein (TRRAP) is a protein related to the ataxia-telangiectasia mutated kinase family. TRRAP has been shown to interact with the oncogene product c-Myc via the amino terminus and with E2F-1 transactivation domain. Mutation and antisense studies of the TRRAP protein resulted in the inhibition of c-Myc- and E2F-1- dependent oncogenesis. TRRAP is a 434-kiloDalton highly conserved protein postulated to be an essential cofactor in carcinogenesis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Oncogenic activity of the c-Myc protein requires dimerization with Max
Article Abstract:
A genetic approach was adopted in the investigation of the role of the Max protein in Myc transformation. It consisted of using Myc and Max mutants that bind to one another but not to their wild-type partners. The mutants were generated by either exchanging the helix-loop-helix-leucine zipper domains of reciprocally modifying leucine zipper dimerization specificities. It was demonstrated that Max is essential to Myc transformation, acting both as suppressor and activator.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Interaction between the origin recognition complex and the replication licensing system in Xenopus
Article Abstract:
The cell-free extracts of Xenopus eggs were analyzed to determine the functions of the origin recognition complex (ORC) and replication licensing factor (RLF) on chromosomal deoxyribonucleic acid (DNA) replication. Analysis of cloned XORC1 gene indicates its action in the licensing of DNA replication that depends on a functional interaction with RLF. However, RLF is not required during the association of XORC1 with chromatin for the licensing of DNA replication.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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