The origins of V(D)J recombination
Article Abstract:
The V(D)J genetic recombination mechanism allows the assembly of antigen receptor cells in T and B cells. The most-understood site-directed recombination mechanisms perform either conservative site-specific recombination (CSSR) or transposition (TPN). There are some similarities of V(D)J with CSSR and TPN. However, V(D)J joining is unique in that it is a two-site interaction that results in inversion or deletion. Also, there are two types of recognition motif in V(D)J instead of one. This limitation which is called the 12/23 rule is what sets apart V(D)J from CSSR and TPN.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Evolution of simple repeats in DNA and their relation to human disease
Article Abstract:
The functions of simple and relation of simple repeats in DNA to human disease has not been completely understood. Various experiments have indicated that diseases associated with the extension of a trinucleotide repeat feature an unstable allele that expands in successive generations. A number of studies have also showed that triplet repeats can be expanded even in the absence of slipped-strand mispairing.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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