Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions

Article Abstract:

Evidence for stable association of proteins at exon-exon junctions is discussed relative to pre-mRNA splicing. The splicing has been shown to change mRNP composition. Several proteins that associate with mRNA exon-exon junctions only as a result of splicing were found through use of a novel in vitro crosslinking approach.

United States, Proteins, Protein crosslinking, Mitosis, RNA splicing, Molecular genetics, Meiosis, Exon (Molecular genetics), Exons (Molecular genetics)

---

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

Article Abstract:

An essential step in eukaryotic gene expression is the removal of introns from nascent transcripts by premRNA splicing. The means by which splicing affects downstream mRNA metabolism is by altering the implement of bound proteins that, together with the mRNA comprise the mRNP.

Eukaryotes, Metabolism, Gene expression, Ribonucleoproteins

---

The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex

Article Abstract:

The concept that nonsense-mediated mRNA decay (NMD) in mammalian cells, which occur during pioneer round of translation that targets CBP80- bound mRNA, is examined with the help of different experiments. Results show some similarities between pioneers round of translation and steady-state translation apart from the differences and further research needs to be carried out to determine the same.

Similar abstracts:

• Abstracts: The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
• Abstracts: Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses. A molecular link between stem cell regulation and floral patterning in Arabidopsis
• Abstracts: The pdx genetic marker adjacent to the chloramphenicol biosynthesis gene cluster in Streptomyces venezuelae ISP5230: functional characterization
• Abstracts: Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria
• Abstracts: Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.