The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae
Article Abstract:
The Y' element is a highly conserved repeat sequence found at some but not all chromosome ends. The function and origin of this repeat sequence is as yet, unknown. To help elucidate these questions, eight Y's from two strains of Saccharomyces cerevisiae were cloned and sequenced. The results showed that the Y' sequence consists of two overlapping open reading frames with no homologies to other known protein sequences, except for the RNA helicases. Further analyses revealed that the Y' elements probably arose from mobile elements, but now translocate via recombination mechanisms.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Site-specific recombination determined by I-SceI, a mitochondrial group I inton-encoded endonuclease expressed in the yeast nucleus
Article Abstract:
The Saccharomyces cerevisiae mitochondrial endonuclease I-SceI is responsible for intron mobility in the mitochondria of yeast. The I-SceI gene was synthesized and expressed in the nucleus. The gene functioned efficiently to catalyze recombination in a manner similar to that initiated by the HO endonuclease gene. However, proteins encoded by these two genes are not related.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switching
Article Abstract:
Mutation in the Mcm1 binding site affects the repression of RE activity in MATa cells indicating the importance of Mcm1. It is a cell binding between Matx2 and Mcm1 that affects RE activity. By affecting the recombination enhancer it also controls the choice of a donor, HML or HMR, in either mating types.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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