The yeast omnipotent suppressor SUP46 encodes a ribosomal protein which is a functional and structural homolog of the Escherichia coli S4 ram protein
Article Abstract:
SUP46, a translation suppressor, encodes the S13 ribosomal protein in yeasts. The ribosomal protein is encoded by two other genes but only SUP46 can complement recessive strains with mutations in the sup46. SUP46 bears significant homology to the product of one of the ribosomal ambiguity genes in Escherichia coli, S4, the equivalent of omnipotent suppressors in prokaryotes. The homology is most pronounced within the central region of the two proteins alterations in which affects binding of the 16S ribosomal RNA.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination
Article Abstract:
A study was conducted to examine the XRS2 gene of Saccharomyces cerevisiae. The possible function of the DNA repair gene in meiotic recombination is investigated. The mutation's suppression of spore inviability of a spo13 rad52 strain suggests action before rad52 in meiotic recombination pathway. However, its meiotic properties do not hamper mitotic recombination processes. Results show that XRS2 cell similarity to rad50 cells present involvement of the former mutation in homologous recombination.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Rearrangements occurring adjacent to a single Ty1 yeast retrotransposon in the presence and absence of full-length Ty1 transcription
Article Abstract:
Structural description of two uncommon deletions in the genome of Saccharomyces cerevisiae is presented. The deletions range from a Ty1 retrotransposon ending in a region near multiple copies of glycine tRNA. Unique sequences bordered by two repetitive elements or flanked by a transposable element are mobile within the genome. Models explaining the generation of these deletions were evaluated by analysis of 32 isolated deletions in the CYC1 segment.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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