Tn5-induced lipopolysaccharide mutations in Bordetella pertussis that affect outer membrane function
Article Abstract:
Tn5 insertion was used to analyze the effects of alteration of LPS on the integrity of the Bertulla pertussis cell wall and on the whole cell. A genomic region of approximately 100kb was cited responsible for the LPS phenotypes with completely lacking LPSA band. Results reveal that alteration in LPS structure in the mutants changed their reactivity to strain-specific mAbs and their sensitivity to hydrophobic and hydrophilic antibiotics.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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Response of the bvg regulon of Bordetella pertussis to different temperatures and short-term temperature shifts
Article Abstract:
A study conducted on the mechanism of activation of late virulence genes in the pathogenic bacteria Bordetella pertussis shows that these genes are activated by a high concentration of BvgA, encoded by the bvgAS locus. An increase in temperature increases the concentration of BvgA and virulence factors formed in the cells. In the presence of a high concentration of BvgA the activation time for the late virulence genes decreases.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1995
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Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity
Article Abstract:
Research was conducted to examine the pathogenicity of Helicobacter pylori with focus on the influence of VacA. A decrease in trans-epithelial resistance across the cell monolayer resulted from the adherence of H. pylori to Madin-Darby canine kidney cells. Results indicate the possibility that increasing the paracellular permeability of the gastric epithelium may be the specific role of VacA in ulcerogenesis.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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