Regulated nucleocytoplasmic transport in spermatogenesis: A driver of cellular differentiation?
Article Abstract:
The hypothesis that regulation of nucleocytoplasmic shuttling is a means of driving differentiation, using spermatogenesis as a model is explored. The nuclear proteins and nucleocytoplasmic transport machinery is consolidated and their functional linkages are highlighted not only as a means of regulating gene transcription and hence cell fate.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
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A long view of fashions in cancer research
Article Abstract:
The models used for cancer research and investigated in molecular terms largely reflect waves of fashion and are proved inadequate. Cancer is a disease of differentiation and there is strong evidence that cancers might have their origin in mutations that block the execution of critical steps in the process of normal differentiation.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
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