Transcriptional oscillation of Lunatic fringe is essential for somitogenesis

Article Abstract:

Transcriptional oscillation of Lunatic fringe (Lfng) has been found to be necessary for somitogenesis. To investigate functional significance of oscillating Lfng activity in somite patterning, transgenic mice were generated. They expressed Lfng in a nonoscillating way in t he presomitic mesoderm using a part of the Delta1 promoter (msf) directing h eterologous gene expression into the paraxial mesoderm.

Germany, Usage, Physiological aspects, Vertebrates, Cytochemistry, Genetically modified mice

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The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation

Article Abstract:

A homeobox gene is identified on the basis of sequence and expression pattern, to represent a murine member of the vertebrate Not gene family. It is shown that this gene is affected by the mouse truncate mutation by complementation test with a targeted null allele and is essential for development of the entire notochord.

Gene mutations, Gene mutation, Nucleotide sequence, Base sequence, Gene expression, Genetic research, Notochord

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WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos

Article Abstract:

T-box-and LEF/TCF-binding sites are essential for activity of the Dll1promoter in the tailbud and presomitic mesoderm, which are regulated by T/TBX6 and WNT signaling. WNT activity, in synergy with TBX6, regulates CLL1 transcription and thereby controls Notch activity, somite formation, and patterning.

Mice as laboratory animals, House mouse

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