Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1
Article Abstract:
Transcriptional repression by a Caenorhabditis elegans germ-line protein has been studied. In the early C. elegans embryo, PIE-1 protein, which is maternally expressed, is necessary in germ-line blastomeres to inhibit somatic differentiation, block phosphorylation of the RNA polymerase II large subunit (Pol II) carboxy-terminal domain (CTD) and maintain mRNA transcription absence. It has been found the PIE-1 can act as a transcriptional repressor in cell culture assays. A PIE-1 repression domain that seems to cut back transcriptional machinery directly has been identified. It seems repressor activity may be important for in vivo PIE-1 function.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
Article Abstract:
The author reviews the publications on hypoxia-inducible transcription factors' regulation. The topics include the regulation of this factor by oxygen availability, the physiological role of the hypoxia-inducible transcription factor's prolyl hydroxylases, and the mediation of hypoxia-inducible transcription factor's activity by Fe(II)-dependent dioxygenase enzyme.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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