Translational regulation in development

Article Abstract:

The translational regulation of mRNA can be brought about by stabilization of 5'UTRs by proteins, masking of RNA to silent mRNP particles, modulation of poly(A) tail length or polyadenylation, trans-acting sequences in the 3'UTR, protein gradients, cell-type switches, and regulation by complementary RNA. Increase in the length of the poly(A) tail increases the rate of translation. Localized mRNA is translated at a faster rate, as in nos and osk mRNA in oocytes, and in this case poly(A) tail length does not play any role in controlling translation.

Genetic translation, Translation (Genetics), Developmental cytology

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Rethinking the microprocessor

Article Abstract:

Some of the structural features of the primary transcript are reported that ensure that the Drosha-DGCR8 enzyme complex liberates precisely the correct precursor sequence, enabling production of a fully functional microRNAs (miRNA). The understanding of how DGCR8 positions Drosha to promote productive pri-miRNA cleavage should help in the search for new miRNA genes and in the design of artificial miRNA genes.

Science & research, Genetic research

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Targeted mRNA degradation by double-stranded RNA in vitro

Article Abstract:

Results show that involvement of double-stranded RNA interference (RNAi) in the gene-silencing events is sequence specific and mediated only by double stranded RNAi targeting specific mRNA for degradation.

United States, Statistical Data Included, Analysis, Gene expression, Genetic transcription, Transcription (Genetics)

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