Leptin-specific patterns of gene expression in white adipose tissue

Article Abstract:

Leptin-specific patterns of gene expression have been studied in white adipose tissue. Leptin is a hormone that regulates body weight by various means. Oligonucleotide microarrays were used to study the response of leptin and of food restriction in wild-type mice, ob/ob mice, and transgenic mice that express a constitutively low level of leptin. An analytical method using k-means clustering was developed and with it genes with similar expression patterns could be grouped. Mice called 'ob/ob mice' are those with mutations in leptin.

Energy metabolism, Genetic regulation, Genetic transcription, Transcription (Genetics), Bioenergetics, Leptin, Body weight, Adipose tissues, Adipose tissue, Genetically modified mice

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Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily

Article Abstract:

Tumor formation and inactivation of RIZ1 are discussed. RIZ1 is an Rb-binding member of a nuclear protein-methyltransferase superfamily. RIZ1 is unusual, having many qualities related to human cancer. Mouse models in which RIZ1, but not RIZ2, was inactivated in mouse models used for research. The RIZ1-deficient mice developed an unusual tumor spectrum and in a genetic background compromised for p53 they had faster tumor formation and mortality.

Statistical Data Included, Gene mutations, Gene mutation, Cancer, Cancer genetics, Transferases, Tumors, Cell nuclei, Cell nucleus

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