Type 2 diabetes TCF7L2 risk genotypes alter birth weight: A study of 24, 053 individuals
Article Abstract:
A hypothesis that fetal TCF7L2 type-2 diabetes predisposing genotypes at rs7903146 and rs12255372 would be associated with reduced birth weight was investigated in individuals from six population-based studies. The first type-2 diabetes susceptibility allele was identified and found to be reproducibly associated with birth weight and common gene variants were found to substantially influence normal birth weight variation.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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A common haplotype of the glucokinase gene alters fasting glucose and birth weight: Association in six studies and population-genetics analyses
Article Abstract:
The role of variation of glucokinase (GCK) in the determination of fasting glucose and birth weight is examined using a tagging single-nucleotide polymorphism (tSNP) approach. A comprehensive analysis of common variation of the glucokinase gene has indicated that this is the first gene to be reproducibly associated with fasting glucose and fetal growth.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects
Article Abstract:
The article describes about the active mutations that are heterozygous in the KCNJ11 gene encodes pore-forming Kir6.2 subunits of the pancreatic beta cell [K.sub.ATP] channel are the most common cause of permanent neonatal diabetes (PNDM).
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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