Translational control of C/EBP(alpha) and C/EBP(beta) isoform expression

Article Abstract:

Regulated initiation of translation from varied sites has been shown to be the main mechanism for generation of different protein isoforms from C/EBP(alpha) and C/EBP(beta) mRNAs. The regulated expression of different C/EBP isoforms depends on the integrity of evolutionarily conserved upstream open reading frames in C/EBP(alpha) and C/EBP(beta) mRNAs. Regulation of translation initiation that determines C/EBP isoform ratio has a vital role in control of cell proliferation and differentiation in C/EBP(alpha)- and C/EBP(beta)-expressing cells.

Cell differentiation, Cell proliferation

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Using viral species specificity to define a critical protein/RNA interaction surface

Article Abstract:

Viral species specificity and its use to define a critical protein/RNA interaction surface are discussed. The molecular basis for the lack of Mason-Pfizer Monkey Virus (MPMV) constitutive transport element (CTE) function in quail cells has been studied/defined. MPMV CTE does not function in the cells because quail Tap (qTap) cannot bind to the CTE. Both CTE binding by qTap and CTE function in quail cells can be restored by changing one residue in qTap to arginine, the residue found at the equivalent position in human Tap (hTap). The Tap protein mediates sequence-specific nuclear export of mRNAs bearing the retroviral CTE. It plays a critical role in the sequence nonspecific export of cellular mRNAs. Potential importance of cross-species genetic complementation in identification /characterization of cellular factors critical for aspects of viral replication has been emphasized.

United States, Biological transport, RNA, Nuclear membranes, Nuclear membrane, Retroviruses, Simian immunodeficiency virus

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Translational control of SCL-isoform expression in hematopoietic lineage choice

Article Abstract:

Research has been conducted on SCL protein expression. The translational regulation of this expression and its role in hematopoietic lineage choice have been investigated, and the results are reported.

Canada, Science & research, Analysis, Proteins, Gene expression, Hematopoiesis, Genetic research

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