Vacuolar biogenesis in yeast: sorting out the sorting proteins
Article Abstract:
The yeast proteins Vps1p and Vps34p control the formation of Golgi complex vesicles, which transport proteins to the vacuoles. Vsp1p in conjunction with adaptins and clathrin controls the constriction and pinching off of the vesicles. Vsp1p is 45% identical to dynamin, a mammalian protein. Vsp34p determines the proteins that are sorted into the vesicles. It is structurally similar to the p85 subunit of the mammalian phosphoinositide-3-kinase. The mechanism of protein transport is conserved in yeast and mammals.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Organelle structure, function, and inheritance in yeast: a role for fatty acid synthesis?
Article Abstract:
The significance of fatty acid synthesis in relation to organelle structure, function and inheritance as observed in Saccharomyces cerevisiae and Schizosaccharomyces pombe as model test systems is discussed. It has been recognized that fatty acid desaturation is important for mitochondrial movement and inheritance. The addition of activated fatty acids to reconstituted secretory transport assay, on the other hand, is known to promote vesicle budding and fusion.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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The yeast spindle pole body is assembled around a central crystal of Spc42p
Article Abstract:
A study was conducted on the yeast spindle pole body (SPB) found in Saccharomyces. The research utilized a cryoelectron microscopy and image processing to determine the structure of isolated diploid SPBs. Results reveal that two lateral-size classes that share similar architecture are present in SPB. Furthermore, A central hexagonally packed layer was observed in tomographic reconstructions of heparin-stripped SPBs.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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