PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
Article Abstract:
The expression of protease-activated receptors (PARs) is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft model. It is demonstrated that matrix metalloprotease in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Vessels and nerves: Marching to the same tune
Article Abstract:
The patterning of the nervous system is achieved through coordinated action of a variety of repulsive or attractive neuronal guidance factors that direct the growth of growing axons to specific pathways. It is suggested that similar sets of factors also guide migration of endothelial cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Vessels and nerves: Marching to the same tune
Article Abstract:
The patterning of the nervous system is achieved through coordinated action of a variety of repulsive or attractive neuronal guidance factors that direct the growth of growing axons to specific pathways. It is suggested that similar sets of factors also guide migration of endothelial cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Planting alfalfa and cloning the Huntington's disease gene. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
- Abstracts: Oncogenes and senescence: Breaking down in the fast lane. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes
- Abstracts: The InsP3 receptor: Its role in neuronal physiology and neurodegeneration. Nonsense-mediated RNA decay: A molecular system micromanaging individual gene and suppressing genomic noise
- Abstracts: Cellulose acetate containing toluidine blue and rose Bengal is an effective microbial coating when exposed to white light
- Abstracts: Transcriptional checkpoints determining the fate of male germ cells. Homeobox galore: When reproduction goes RHOX and Roll