When checkpoints fail
Article Abstract:
The DNA damage response checkpoint reacts in vastly different ways to different types of damage, to different stages of cell cycle arrest and in different tissues of metazoans. It acts at three stages in the cell cycle: one at the G1/S transition, one that monitors progression through S and one at the G2/M boundary. Although these respond to different types of damage and arrest the cell at different stages, a number of the same components are involved at all three arrests. One common element is that many types of DNA damage are processed to single-stranded DNA and the latter is apparently the direct signal in bacteria, Xenopus, human cells and possibly even Saccharomyces cerevisiae.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
Article Abstract:
The cell cycle in the S phase of S. cerevisiae is slowed down when alkylation of DNA takes place. Mec1 and rad53 genes are responsible for slowing down of replication but mutants in mec1 and rad53 genes are capable of replicating damaged and undamaged DNA, indicating that the process is controlled by another factor, which is probably present in the S phase of cell cycle. Mec1 is a gene that has a similar function as the ATM gene in humans, mutations in which cause ataxia telangiectasia.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
Article Abstract:
A sing double-stranded DNA (dsDNA) break will lead to yeast cell arrest in G2/M at the damage checkpoint. Two adaptation-defective mutants remaining permanetly arrested when faced with irreparable dsDNA break have been identified. One mutation resides in CDC5, and the other less penetrant, adaptation-defective mutant is affected at the CKB2 locus.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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