Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal

Article Abstract:

A DYRK family kinase, Yak1p, has been found to phosphorylate yeast Pop2p as a response to a glucose signal. It also translocates to the nucleus. The 97th threonine residue of Pop2p is phosphorylated, and Yak1p interacts with Bmh1p and Bmh2p only when glucose is present. The glucose-sensing system is involved in growth control.

Japan, Cells (Biology), Growth, Yeast, Yeast (Food product), Cells, Protein kinases, Glucose, Brewer's yeast, Saccharomyces cerevisiae

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Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain

Article Abstract:

Effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain have been studied and found to oppose one another. The elongation-associated phosphorylation of Ser 2 was seen to be dependent on the Ctk1 kinase, a putative yeast homolog of Cdk9/P-TEFb. It appears that regulation of transcription elongation by Crk1 And Fcp1 may occur by modulating levels of Ser2 phosphorylation, which may then regulate the association of elongation factors with the polymerase.

South Korea, Canada, Genetic transcription, Transcription (Genetics), RNA polymerases, Saccharomyces, Messenger RNA

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