lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48

Article Abstract:

Two class B synthetic multivulva (synMuv) genes, lin-35 and lin-53, in one of the two functionally redundant pathways of Caenorhabditis elegans are characterized. The purpose of this exercise is to study the molecular processes that determine how SynMuv genes constrain vulval induction. Results of the analysis reveal that vulval development in pathways mediated by the tumor suppressor Rb in C. elegans serves as antagonist of the receptor tyrosine kinase/Ras pathway of vulval induction.

Analysis, Carrier proteins, Transport proteins, Protein tyrosine kinase, Protein-tyrosine kinase, Tumor suppressor genes, Ras genes

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EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins

Article Abstract:

Periodic activities in the nematode Caenorhabditis elegans are regulated by the concentrations of a protein produced by the gene egl-10. These activities, such as the way the body bends during movement and the frequency of egg laying, require a threshold level of EGL protein whose activity is in turn regulated by a G protein. The EGL protein structure is similar to the G protein regulator found in yeast, and implies the existence of a family of G protein regulators in all animals.

Genetic aspects, Neural transmission, Synaptic transmission

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Crystal structure at 2.4 angstrom resolution of the complex of transduction betagamma and its regulator, phosducin

Article Abstract:

Transducin is a G protein involved in the signal transduction system. Crystal structure determination of transducin's betagamma subunits at 2.4 angstroms resolution identified two domains: the N-terminal domain that binds loops on the protein's surface, and the C-terminal domain which binds the outer strands of the effector molecules. The activity of transducin's regulator, phosducin, was inhibited by the phosphorylation of phosphoducin at Ser-73 which leads to mutations.

Transducin

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