vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain
Article Abstract:
Research has been conducted on the homeobox gene vHnf1 mutations associated with the maturity-onset diabetes of the young, type V and glomerulocystic kidney disease. The isolation of the zebrafish vhnf1 mutant alleles has been carried out and the results indicate that the mutants' phenotypes include kidney cyst formation and pancreas and liver underdevelopment, demonstrating that these abnormalities arise from the patterning defects during development.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Gata5 is required for the development of the heart and endoderm in zebrafish
Article Abstract:
The zinc finger transcription factor Gata5 encoded by the faust locus has been shown to be necessary for the development of the endoderm and heart in zebrafish. Gata5 regulates expression of the early myocardial gene nkx2.5. Mechanisms regulating vertebrate heart and endoderm development are now of much interest. Evidence from gain-of-function and loss-of-function experiments is presented.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Zebrafish mutations and functional analysis of the vertebrate genome
Article Abstract:
Recent advances in genomic resources that will add to cloning mutated zerbrafish genes by positional cloning, insertional mutagenesis, the candidate gene approach are reviewed. Facile genetics of zebrafish allow for rapid isolation of mutations. Phenotypic analysis can show gene functions difficult to find in other systems.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
- Abstracts: The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo
- Abstracts: Broad-host-range shuttle vectors for screening of regulated promoter activity in viridans group streptococci: isolation of a pH-regulated promoter
- Abstracts: Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
- Abstracts: Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum