A quantitative analysis of kinase inhibitor selectivity

Article Abstract:

A wide diversity of interaction maps for 38 kinase inhibitors, quantified and differentiated by using the concept of a selectivity score is presented. The studies provide insight into therapeutic activity of kinase inhibitors to inhibit multiple targets and interaction of inhibitors with the human kinome.

Enzyme Inhibitors, Analysis, Mutation (Biology), Mutation, Phosphotransferases

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Uninhibited antibiotic target discovery via chemical genetics

Article Abstract:

An integrated high-throughput screening and multicopy suppression method for concomitant identification of new antimicrobial compounds is presented. The studies show that the method assists in identifying potential resistance mechanisms of new antimicrobial compounds and their bacterial targets.

Product development, Biochemical genetics

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The new antibiotics. Can novel antibacterial treatments combat the rising tide of drug-resistant infections?

Article Abstract:

New antibiotics are needed to combat an every increasing number of infectious diseases that are resistant to the current drugs. Research being conducted by many drug companies is discussed, and diagrams, tables, and related sidebars are included.

United States, Systemic Antibiotic Preparations, Antibiotics

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